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Scientists discover an untapped pharmaceutical resource in the deep sea
Chinese marine scientists have identified a large number of previously unknown microbial natural products from the deep seabed that may have pharmaceutical applications.
In the cold seeps of the deep sea, microbial communities thrive on geological seepage of hydrocarbons and inorganic compounds for sustenance, in stark contrast to the sunlight-dependent ecosystems people are more familiar with on the surface.
These organisms use biosynthetic gene clusters (BGCs) to synthesize natural products that help them compete for resources. This unknown natural product is believed to have powerful anti-microbial properties, which could be a game-changer in the fight against drug-resistant infections.
The team of scientists, led by researchers from the Third Institute of Oceanography under the Ministry of Natural Resources, analyzed 22 sediment cores from nine cold seeps, and detected BGCs encoding natural products from 63 archaeal and bacterial phyla.
Many of the BGCs they found likely encode antimicrobial compounds, serving as chemical weapons for host defense and competition in microbial communities, according to a study recently published in the journal Science Advances.
The discovery provides a pathway to identify previously unknown antimicrobial compounds and other types of drugs, according to the researchers.
